of the following describes why a drug may appear effective against a pathogen in clinical susceptibility tests but ineffective in a real-life context?…

Which of the following describes why a drug may appear effective against a pathogen in clinical susceptibility tests but ineffective in a real-life context?

Drug susceptibility tests are typically performed at room temperature (much cooler than human body temperature).

In clinical susceptibility tests, drug concentration is well controlled compared to a real-life context.

Compared to controlled susceptibility tests, the drug may be less active in a real-life context either due to drug inactivation by body processes or as a result of drug solubility issues.

Unlike in controlled clinical susceptibility tests, the number of bacteria varies between tissue samples.